09-08
Adaptive Designs for Dose Escalation Studies
by Roth, K.
Preprint series: 09-08, Preprints
- MSC:
- 62K05 Optimal designs
- 62L05 Sequential design
- 62P10 Applications to biology
Abstract: In Phase I dose escalation studies the 3+3 design is a commonly used method. We suggest a modification of this method to include a parametric model and the concepts of optimal design theory, with the aim of improving this method. The performance of the original and the new approach are investigated by simulations.
Keywords: optimal design, adaptive design, dose escalation studies
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